The Effect of Resveratrol against Acrolein Toxicity in Mitochondria isolated from Rat Liver

Inhibitory Effects of Resveratrol against Mitochondrial Toxicity Induced by Perfluorooctanoic Acid in Isolated Liver Mitochondria of Male Rats

 Background and purpose: Resveratrol (RSV) is a naturally polyphenolic compound found in grapes and other plant sources. It has potent free radical scavenger and antioxidative properties.The aim of this study was to evaluate the protective effect of resveratrol against Perfluorooctanoic acid (PFOA) induced mitochondrial toxicity in isolated liver mitochondria. Materials and methods: Mitochondr...

Protective Effect of Captopril against Doxorubicin-Induced Oxidative Stress in Isolated Rat Liver Mitochondria

      Doxorubicin (DOX) is an anthracycline antibiotic that has been used for a long time in therapy of an array of human malignancies either alone or in combination with other cytotoxic agents. The dose-dependent cardiotoxicity of DOX significantly limits its anticancer efficacies. Oxidative stress caused by enhanced production of reactive oxygen species is an important contributor to DOX mito...

Comparison of the Protective Effects of Curcumin and Nanocurcumin on Acrolein Induced Mitochondrial Toxicity Isolated from Rat Liver

Background and Objectives: Contact with acrolein rapidly reduces intracellular glutathione and its antioxidant capacity and causes mitochondrial dysfunction. The use of some polymeric nanocurcumin increases the stability of curcumin. In this study, the effect of these two, was investigated on acrolein-induced toxicity in mitochondria isolated from rat liver cells.   Methods: In this experiment...

molecular mechanism of metamphetamine toxicity in isolated rat liver mitochondria

A Comparison of Toxicity Mechanisms of Cigarette Smoke on Isolated Mitochondria Obtained from Rat Liver and Skin

Previous studies demonstrated that CSE induces oxidative stress and its consequences on isolated mitochondria obtained from lung, heart and brain which may provide insight into the role of CSE in human health and disease. The present study was carried out to further characterize and compare toxic effect of CSE extract on isolated mitochondria obtained from either a directly contacting tissue (i...

Study of the Effects of ATP Suppliers and Thiol Reductants on Toxicity of Pioglitazone in Isolated Rat Liver Mitochondria

Pioglitazone (PG) is one of thiazolidinediones used for the treatment of type II diabetes mellitus. Some reports of its hepatotoxicity exist, but the mechanism of its hepatotoxicity is not well known. In the present study, the protective effect of some ATP suppliers are investigated against mitochondrial toxicity of PG in isolated rat mitochondria. Mitochondrial viability was investigated by MT...